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Cytotoxic T Lymphocytes-Medical College of Wisconsin-Adenovirus infection-Cytomegalovirus infection-Epstein-Barr virus infection
- Development stage
- Unknown
- Lead developer
- Medical College of Wisconsin
- Modality
- Cell Therapies
- Administration
- Intravenous
01
Overview
Multi-virus Cytotoxic T Lymphocytes (CTLs) is an investigational adoptive cellular immunotherapy developed by the Medical College of Wisconsin. The product consists of donor-derived, polyclonal CD4+ and CD8+ T cells that have been expanded ex vivo to specifically recognize and target immunodominant antigens from three common opportunistic viruses: Adenovirus (Ad), Cytomegalovirus (CMV), and Epstein-Barr virus (EBV). This therapy is primarily intended for prophylaxis in pediatric recipients of T-cell depleted allogeneic hematopoietic progenitor cell transplants (HPCT). These patients are at high risk for life-threatening viral infections due to the severe immunosuppression resulting from the removal of T cells from the graft. By restoring virus-specific immunity through the infusion of these trained CTLs, the therapy aims to prevent viral reactivation and disease without inducing graft-versus-host disease (GVHD).
- Other names
- Multi-virus Cytotoxic T LymphocytesMulti-virus Cytotoxic T-cellsAd-CMV-EBV-specific CTLs
02
Targets
pMHC-I (Peptide–MHC class I complex)Ad-pMHC-I (Adenovirus peptide-major histocompatibility complex class I)
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