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Drug intelligence / Profile preview
D-2-18F-α-methyl-phenylalanine
- Development stage
- Preclinical
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Positron Emitters → Radiopharmaceuticals, Small Molecules
- Administration
- Intravenous
01
Overview
D-2-18F-α-methyl-phenylalanine is an F-18-labeled amino acid radiotracer developed for Positron Emission Tomography (PET) imaging. It is being evaluated for the diagnosis of various cancers, including bladder cancer, glioblastoma, and gliosarcoma. The drug is designed to leverage the increased amino acid metabolism and upregulated amino acid transporters in tumor cells, allowing for their visualization. Its properties include rapid blood clearance and low renal accumulation, which are advantageous for imaging applications where background radioactivity from urine can interfere, such as in bladder cancer detection.
02
Targets
SLC7A5 (Large neutral amino acid transporter small subunit 1)SNAT2 (Sodium-coupled neutral amino acid transporter 2)SLC7A10 (Alanine-serine-cysteine transporter 1)
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