D-Ala2 glucose-dependent insulinotropic polypeptide

D-Ala2 glucose-dependent insulinotropic polypeptide (also known as [D-Ala2]-GIP) is a synthetic, enzymatically stable analog of the incretin hormone glucose-dependent insulinotropic polypeptide (GIP). It features a D-alanine substitution at position 2, which confers resistance to degradation by dipeptidyl peptidase-4 (DPP-4), thereby significantly prolonging its half-life and biological activity compared to native GIP. [D-Ala2]-GIP acts as a potent agonist of the GIP receptor (GIPR), stimulating glucose-dependent insulin secretion and improving glucose tolerance. It is widely utilized as a research tool to investigate the physiological roles of GIP signaling in glucose homeostasis, bone metabolism, and neuroprotection, showing beneficial effects in preclinical models of type 2 diabetes, Alzheimer's disease, and Parkinson's disease.

Other names

(D-Ala2) gastric inhibitory polypeptide(D-Ala2)GIPD-Ala2 gastric inhibitory polypeptideD-Ala-2 gastric inhibitory polypeptideD-Ala 2 gastric inhibitory polypeptideD-Ala2-GIPD-Ala-2-GIPD-Ala 2-GIP[D-Ala2] gastric inhibitory polypeptide[D-Ala2] glucose-dependent insulinotropic polypeptide[D-Ala2]GIP[D-Ala2]GIP(1-42)[D-Ala2]-GIP[D-Ala2]-GIP (human)