d-alanine2-glucagon-like peptide-1

d-alanine2-glucagon-like peptide-1 is a synthetic peptide analog of the human incretin hormone glucagon-like peptide-1 (GLP-1). It is specifically engineered with a D-alanine substitution at the second amino acid position (replacing the naturally occurring L-alanine), which confers resistance to rapid degradation by the enzyme dipeptidyl peptidase-4 (DPP-4). This modification significantly extends the peptide's biological half-life while maintaining its potency as an agonist for the glucagon-like peptide-1 receptor (GLP1R). The drug functions by stimulating glucose-dependent insulin secretion from pancreatic beta cells, inhibiting glucagon release, and slowing gastric emptying. Research has primarily focused on its potential for treating Type 2 diabetes mellitus, including the development of oral delivery systems using polymer-based microspheres to improve bioavailability and patient compliance.

Other names

D-Ala2-glucagon-like peptide-1D-Ala-2-glucagon-like peptide-1D-Ala 2-glucagon-like peptide-1[D-Ala2]glucagon-like peptide-1(7-36)amideD-alanine2-GLP-1D-alanine-2-GLP-1D-alanine 2-GLP-1