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D-Aspartic Acid
- Development stage
- Phase 1
- Lead developer
- Relmada Therapeutics
- Modality
- Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
D-Aspartic Acid (D-Asp) is a naturally occurring D-amino acid found in various tissues, including the central nervous system, endocrine glands, and exocrine tissues like salivary glands. It is also present in certain foods and available as a dietary supplement. D-Asp plays a role as a signaling molecule in the nervous and neuroendocrine systems, influencing the release and synthesis of hormones such as luteinizing hormone (LH), follicle-stimulating hormone (FSH), growth hormone (GH), prolactin, oxytocin, vasopressin, and testosterone. It also functions as an endogenous neurotransmitter and agonist of the N-methyl-D-aspartate receptor (NMDAR), contributing to neuroplasticity and brain activity. D-Asp has been investigated for its potential to improve fertility, boost testosterone levels, and reduce symptoms of schizophrenia, although research findings are mixed and further studies are needed.
- Brand names
- DAA
- Other names
- D-AspD-aspartateaminosuccinic acid
02
Targets
AMPAR (AMPA receptor)mGluR (Metabotropic glutamate receptors)NMDAR (Glutamate receptor ionotropic, NMDA)GnRHR (Gonadotropin-releasing hormone receptor)GHRHR (Growth hormone-releasing hormone receptor)DRD2 (Dopamine D2 Receptor)
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