D-carnosine octylester

D-carnosine octylester is a synthetic lipophilic prodrug of D-carnosine, the D-enantiomer of the endogenous dipeptide carnosine. It is designed to enhance oral bioavailability and tissue delivery, overcoming the rapid degradation of carnosine by carnosinase in humans. As a prodrug, it releases active D-carnosine in vivo. D-carnosine octylester acts as a selective and potent scavenger of reactive carbonyl species (RCS), such as 4-hydroxy-2-nonenal (HNE), by forming stable adducts and preventing the formation of advanced lipoxidation end products (ALEs) and advanced glycation end products (AGEs). In preclinical models, D-carnosine octylester attenuates atherosclerosis, renal disease, and diabetes-induced vascular complications through reduction of carbonyl stress and inflammation. The primary mechanism is believed to be RCS quenching, reducing protein carbonylation, circulating ALEs/AGEs, tissue oxidative stress, and downstream inflammatory signaling[1][2][3][7].

Other names

D-carnosine octyl esterD-carnosine-octylestercarnosine octyl estercompound 13compound13compound-13