d-eritadenine

D-Eritadenine is a naturally occurring purine alkaloid found in shiitake mushrooms (Lentinula edodes) and other fungi. It is an adenosine analog and a member of the 6-aminopurines class. D-Eritadenine acts as a potent, reversible inhibitor of S-adenosyl-L-homocysteine hydrolase (SAHH), an enzyme involved in methylation reactions within cells[2][4][5][8]. Through this inhibition, D-eritadenine can disrupt methylation-dependent biological processes. The compound has demonstrated hypocholesterolemic activity in animal studies by altering liver phospholipid metabolism, leading to enhanced removal or reduced release of cholesterol from the liver[5][10]. Its mechanism for lowering cholesterol does not involve direct inhibition of cholesterol biosynthesis but rather modulation of lipid handling by the liver. D-Eritadenine has also shown antiviral properties due to its SAHH inhibitory action[8]. There are no approved pharmaceutical uses for D-eritadenine; it remains primarily an experimental compound studied for its biochemical effects.

Other names

eritadeninelentinacinlentysineleutinacind-erythro-eritadenine4-(9-Adenyl)-D-erythro-2,3-dihydroxybutyric acid