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d-fluoromethyltyrosine f-18
- Development stage
- Phase 1
- Lead developer
- Bayer
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
D-fluoromethyltyrosine F-18 is a radiopharmaceutical tracer used in positron emission tomography (PET) imaging. It is a novel 18F-labeled tyrosine derivative that is rapidly transported by the L-amino acid transporter (LAT-1) with faster blood pool clearance than the corresponding L-isomer. The D-isomer of 18F-FMT provides better tumor-to-blood and tumor-to-liver ratios compared to the L-isomer, making it valuable for tumor detection and monitoring early-phase response to radiation therapy. The radioisotope fluorine-18 has a half-life of approximately 110 minutes and decays by positron emission (97%) and electron capture (3%).
- Other names
- O-18F-fluoromethyl-D-tyrosineO18F-fluoromethyl-D-tyrosineO 18F-fluoromethyl-D-tyrosine
02
Targets
SLC7A5 (Large neutral amino acid transporter small subunit 1)
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