d-fraction polysaccharide

D-fraction polysaccharide is a **protein-bound beta-glucan polysaccharide extract** from the maitake mushroom (*Grifola frondosa*), containing 1,3- and 1,6-beta-glucans as its main active components[5][2][3]. It exhibits **immunomodulatory, antitumor, and potential antidepressant activities**. D-fraction enhances immune functions by modulating natural killer (NK) cells, T-cells, and macrophages, and inhibits tumor growth in animal models and some human studies, with demonstrated activity in breast, prostate, lung, and liver cancers[5][2][1]. It may work as an adjunct in cancer therapy, helping mitigate side effects of chemotherapy and improving quality of life[5]. D-fraction also shows potential in management of chronic fatigue syndrome, HIV/AIDS, and metabolic conditions like diabetes and hypercholesterolemia[5][2]. Experimental evidence suggests a rapid-acting, long-lasting antidepressant effect in animals, with possible reduction of inflammatory pain symptoms[3]. D-fraction appears to be well tolerated, with no significant adverse effects reported[3][5].

Brand names

Maitake D-FractionD-fraction

Other names

Maitake PDFMaitake D-fractionMaitake polysaccharide D-fractionprotein-bound polysaccharide (Maitake)