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d-MAPPS Ophthalmic Solution

Development stage: Phase 3
Lead developer: Regenerative Ocular Immunobiologics
Administration: Ophthalmic, Topical

Overview

d-MAPPS Ophthalmic Solution is an investigational, platelet-derived biologic eye drop developed by Regenerative Ocular Immunobiologics LLC for the treatment of chronic ocular graft-versus-host disease (oGVHD). oGVHD is a severe inflammatory condition that occurs when donor immune cells attack the recipient's ocular tissues following a bone marrow or stem cell transplant. The drug is a sterile, preservative-free solution containing a complex mixture of platelet-derived growth factors and cytokines designed to reduce ocular surface inflammation and promote tissue repair. It is currently being evaluated in a Phase 3 pivotal clinical trial (NCT06852768) to assess its efficacy in improving ocular comfort and surface integrity in adult patients.

Brand names: d-MAPPS
Other names: d-MAPPS Ophthalmic Solution

Targets

TRPV4 (Transient receptor potential cation channel subfamily V member 4)IL1R1 (Interleukin-1 Receptor Type 1)TNFA (Tumor necrosis factor alpha (soluble))

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