d-naphthyl-1-acetamido boronic acid alanine

D-naphthyl-1-acetamido boronic acid alanine is a synthetic small molecule belonging to the class of naphthalene derivatives. It functions as a transition-state analog inhibitor of serine proteases, specifically designed to mimic the tetrahedral intermediate formed during peptide bond hydrolysis. This compound has been studied primarily in biochemical and structural biology research as an experimental inhibitor for enzymes such as subtilisin Carlsberg and gamma-chymotrypsin. The D-enantiomer, in particular, exhibits unique binding properties compared to its L-counterpart, forming covalent adducts with the catalytic serine residue of target proteases[4][9]. There are no approved therapeutic indications or clinical uses for this compound; it is used exclusively in experimental settings.

Other names

D-Naphthyl-1-Acetamido Boronic Acid AlanineD-Naphthyl1-Acetamido Boronic Acid AlanineD-Naphthyl 1-Acetamido Boronic Acid Alanine((2S)-2-amino-2-carboxyethoxy)((1S)-1-acetamido-2-(naphthalen-1-yl)ethyl)dihydroxyboranuide[(2S)-2-amino-2-carboxyethoxy][(1S)-1-acetamido-2-(naphthalen-1-yl)ethyl]dihydroxyboranuide[(1S)-1-(acetylamino)-2-naphthalen-1-ylethyl](dihydroxy)(L-serinato-kappaO~3~)borate(1-)Q27096348Q-27096348Q 27096348