d rhamnose β-hederin

D rhamnose β-hederin (DRβ-H) is a novel oleanane-type triterpenoid saponin isolated from the traditional Chinese medicinal plant *Clematis ganpiniana*. It is currently in the preclinical research stage, primarily investigated for its anti-tumor activity in breast cancer. DRβ-H exerts its effects by inhibiting the PI3K/AKT signaling pathway and activating the ERK signaling pathway, leading to the induction of apoptosis via the mitochondrial pathway (regulating Bcl-2 family proteins and activating caspases). Additionally, it has been shown to inhibit cancer cell migration and invasion by upregulating RNPC1 and E-cadherin and suppressing tumor-derived exosome secretion. It also demonstrates potential in reversing chemoresistance to agents like docetaxel and adriamycin in breast cancer cells.

Other names

D rhamnose + β-hederinD Rhamnose β-hederin3β-[(α-L-arabinopyranosyl)-oxy] olean-12-en-28-oic acid