Drug intelligence / Profile preview

D4476

Development stage
Unknown
Lead developer
Beth Israel Deaconess Medical Center
Modality
Small Molecules
Administration
Oral
01

Overview

D4476 is a **small-molecule casein kinase 1 inhibitor** used primarily as a research tool rather than an approved medicine. Across the cited literature, it is consistently described as a selective inhibitor of **casein kinase 1 alpha**, and it is used to probe CK1alpha-dependent signaling in cancer, red blood cell injury, inflammation, infection biology, steroidogenesis, and viral replication. Reported experimental findings link D4476 to modulation of pathways involving ferroptosis, pyroptosis, interferon receptor regulation, alpha-enolase phosphorylation and localization, ovarian granulosa-cell estradiol production, and Rift Valley fever virus replication. The provided evidence supports its identity as an investigational laboratory compound with broad preclinical pharmacology, but not as a clinically developed therapeutic product.

Other names
casein kinase 1 inhibitor D4476CK1 inhibitor D4476CK-1 inhibitor D4476CK 1 inhibitor D4476CK1alpha inhibitor D4476CK-1alpha inhibitor D4476CK 1alpha inhibitor D4476
02

Targets

CSNK1G3 (Casein kinase 1 gamma 3)CK1α (Casein kinase I alpha)TGFBR1PKD (Protein kinase D family)CSNK1D (Casein kinase I delta)RK (Ribokinase)

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