d6-25-hydroxyvitamin D3

D6-25-hydroxyvitamin D3 (hexadeuterated 25(OH)D3) is a stable isotope-labeled tracer used in pharmacokinetic research to study the metabolism and clearance of vitamin D. Developed and utilized by researchers at the University of Washington, specifically in the CLEAR (Clearance of 25-hydroxyvitamin D in Chronic Kidney Disease) study, this compound allows for the precise measurement of 25-hydroxyvitamin D3 (calcifediol) clearance rates without the risks associated with radioactive tracers. It is primarily used as a research tool to investigate how chronic kidney disease (CKD) and factors like race or vitamin D supplementation affect the metabolic breakdown and elimination of vitamin D3 metabolites. By administering the compound intravenously, researchers can track its clearance through the vitamin D metabolic pathway, providing insights into the pathophysiology of vitamin D deficiency in CKD patients.

Other names

hexadeuterated 25-hydroxyvitamin D3hexadeuterated25-hydroxyvitamin D3hexadeuterated-25-hydroxyvitamin D3hexadeuterated 25(OH)D3D6-25-hydroxyvitamin D3-University of Washington-chronic kidney diseaseD-6-25-hydroxyvitamin D3-University of Washington-chronic kidney diseaseD 6-25-hydroxyvitamin D3-University of Washington-chronic kidney diseasedeuterium-labeled 25-hydroxyvitamin D3deuterium-labeled25-hydroxyvitamin D3deuterium-labeled-25-hydroxyvitamin D3