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D745
- Development stage
- Unknown
- Lead developer
- Chong Kun Dang Pharmaceutical
- Modality
- Nucleic Acid-Directed Small Molecules → Small Molecules, Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
D745 is a small molecule antihyperglycemic agent under development as part of a fixed-dose combination therapy (CKD 383) with lobeglitazone and D150 by Chong Kun Dang. The combination is being investigated for the treatment of type 2 diabetes mellitus. D745 belongs to the pyrimidine class and acts as an agonist at peroxisome proliferator-activated receptor alpha (PPARα) and peroxisome proliferator-activated receptor gamma (PPARγ), which are nuclear hormone receptors involved in glucose and lipid metabolism. Activation of these receptors improves insulin sensitivity, making this drug candidate relevant for metabolic disorders such as type 2 diabetes[4].
- Other names
- CKD 501/D745/D150/D029CKD 383CKD383CKD-383
02
Targets
PPARG (Peroxisome proliferator-activated receptor gamma)PPARA (Peroxisome proliferator-activated receptor alpha)
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