DA + CPT-KK-3E8

DA + CPT-KK-3E8 is an experimental, targeted nanoparticle delivery system designed for the treatment of cancers expressing Tumor-Associated Glycoprotein 72 (TAG-72). The platform consists of a self-assembled nanotube core formed by camptothecin conjugated to a dilysine peptide (CPT-KK), which is stabilized by a layer of polydopamine (PDA). The surface of this PDA-stabilized nanotube is functionalized with 3E8, a single-chain variable fragment (scFv) that specifically targets the TAG-72 antigen, which is overexpressed in various adenocarcinomas, including colorectal, ovarian, and breast cancers. Once the nanoparticle binds to and is internalized by the target cancer cell, the camptothecin payload acts as a potent DNA topoisomerase I inhibitor, inducing double-strand DNA breaks and subsequent apoptosis. This modular platform is designed to improve the solubility and therapeutic index of camptothecin while minimizing systemic toxicity through active tumor targeting.

Other names

PDA-CPT-KK-3E8PDA-CPT-KK3E8PDA-CPT-KK 3E83E8-PDA-CPT-KK3E8-functionalized PDA-CPT-KK nanotube