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DA-3502
- Development stage
- Preclinical
- Lead developer
- Dong-A ST
- Modality
- Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics, Cytotoxic ADCs → Antibody-Drug Conjugates (ADCs) → Antibody Conjugates → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
DA-3502 is an investigational bispecific antibody-drug conjugate (bsADC) being developed by Dong-A ST for the treatment of oncology indications. It is designed to simultaneously target Claudin 18.2 (CLDN18.2) and Human Epidermal Growth Factor Receptor 2 (HER2), two tumor-associated antigens that are frequently co-expressed in gastrointestinal cancers, such as gastric and gastroesophageal junction adenocarcinomas. By co-targeting these two proteins, DA-3502 aims to improve tumor-targeting selectivity, enhance internalization, and overcome resistance mechanisms associated with single-antigen therapies. The program is currently in the early discovery and hit optimization stages of development.
02
Targets
Claudin 18.2ERBB2 (Erb-b2 receptor tyrosine kinase 2)
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