dabigatran etexilate + diclofenac

This product is a combination of **dabigatran etexilate**—an oral direct thrombin inhibitor anticoagulant—and **diclofenac**—a nonsteroidal anti-inflammatory drug (NSAID). Dabigatran etexilate works by **inhibiting thrombin (factor IIa), preventing the formation of fibrin clots**[1][5][9]. Diclofenac acts by **inhibiting cyclooxygenase (COX-1 and COX-2) enzymes, reducing prostaglandin synthesis and inflammation**. The dual use is clinically notable for a significantly increased risk of bleeding due to the synergistic effects of anticoagulation and antiplatelet activity[1][3][7]. This combination is not marketed as a fixed-dose product but is discussed here as concurrent use of both agents.

Brand names

PradaxaVoltaren

Other names

dabigatran etexilate + diclofenac