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Dabuyin Wan
- Development stage
- Unknown
- Lead developer
- Huqing Yutang
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Dabuyin Wan is a classical Traditional Chinese Medicine (TCM) formulation presented as a dark brownish-black water-honeyed pill. It is a multi-ingredient herbal preparation composed of five primary ingredients: Radix Rehmanniae Preparata (Shudi Huang), Rhizoma Anemarrhenae (Zhimu), Cortex Phellodendri (Huangbai), processed Carapax et Plastrum Testudinis (Guiban), and Medulla Spinalis Suis (Zhuizhui). In TCM practice, it is used to 'nourish yin and lower fire,' and is indicated for conditions involving yin deficiency with flaming-up of fire, manifested by symptoms such as daily recurring fever, night sweating, cough, hemoptysis, tinnitus, and seminal emission. Modern research has investigated its potential in treating central precocious puberty (CPP) and early puberty in children. The proposed mechanism involves the down-regulation of Kiss-1/GPR54 mRNA expression in the hypothalamus, which inhibits the synthesis and release of gonadotropin-releasing hormone (GnRH), thereby suppressing the hypothalamic-pituitary-gonadal axis.
- Brand names
- Dabuyin Wan
- Other names
- Dabuyin PillsDabu Yin Wan大补阴丸大補陰丸
02
Targets
AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)
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