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Dacus Carota Exosomes
- Development stage
- Preclinical
- Lead developer
- Institute of Liver and Biliary Sciences
- Modality
- Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
- Administration
- Oral
01
Overview
Dacus Carota Exosomes (DC-Ex) are plant-derived extracellular vesicles (exosomes) isolated from black carrots (*Dacus Carota L spp.*). They are being developed as a therapeutic intervention for hepatic encephalopathy (HE) in patients with chronic liver disease. DC-Ex are enriched with bioactive phytochemicals, including anthocyanins, quercetin, dopamine, 3-O-glucoside, xanthotoxin, and tangeretin. The therapeutic mechanism involves modulating the gut-liver-brain axis by restoring gut microbial homeostasis, specifically by increasing beneficial Firmicutes (such as *Lachnoclostridium* and *Bacteroides*) and decreasing urease-producing taxa like *Escherichia-Shigella*. This modulation leads to a reduction in blood ammonia levels, improved gut mucosal integrity through enhanced junctional communications, and improved cognitive and sensory-motor functions. The drug is currently in early development, with research led by the Institute of Liver and Biliary Sciences.
- Other names
- black carrot exosomesDacus Carota L spp. Exosomesblack carrot extracellular vesiclesDC-Exosomes
02
Targets
UreaseOCLN (Occludin)
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