DADLE

DADLE ([D-Ala2, D-Leu5]-Enkephalin) is a synthetic opioid peptide and an analog of enkephalin. It acts primarily as a selective agonist at the delta opioid receptor (δ-opioid receptor), but also displays activity at the mu opioid receptor (μ1 subtype). As an experimental analgesic agent, it exhibits antinociceptive properties in vivo and has been shown to cause transient depression of mean arterial blood pressure and heart rate. In preclinical studies, DADLE demonstrates cytoprotective effects in models of ischemia-reperfusion injury and neuroprotection via activation of prosurvival kinases such as Akt and ERK1/2. Its mechanism involves both direct δ-opioid receptor activation and possible transactivation pathways involving EGFR signaling[1][4][6][7]. The peptide sequence is Tyr-D-Ala-Gly-Phe-D-Leu.

Other names

[D-Ala2, D-Leu5]-EnkephalinTyr-D-Ala-Gly-Phe-D-Leuenkephalin analog