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dagrocorat
- Development stage
- Unknown
- Lead developer
- Pfizer
- Modality
- Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Dagrocorat (also known as Fagrocorat) is a synthetic small molecule that acts as a selective glucocorticoid receptor modulator. It exerts anti-inflammatory effects by binding to the glucocorticoid receptor and modulating gene expression involved in inflammatory responses. This results in suppression of pro-inflammatory cytokines and mediators. Dagrocorat is an active metabolite of the prodrug fosdagrocorat and has been investigated primarily for the treatment of rheumatoid arthritis. Its unique structural features include a trifluoromethyl group and phenanthrene core, which contribute to its pharmacokinetic and pharmacodynamic properties[3][4][5][8].
- Other names
- Fagrocorat1044535-52-5UNII-OPM23UN90UUNII-OPM-23UN90UUNII-OPM 23UN90U
02
Targets
GR (Glucocorticoid receptor)
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