Drug intelligence / Profile preview

dahuang gancao tang

Development stage
Phase 2
Lead developer
Changhua Christian Hospital
Administration
Oral
01

Overview

DaHuang GanTsao Tang is a traditional Chinese herbal formula (TCM) consisting of two primary botanical components: *Rheum palmatum* (Rhubarb) and *Glycyrrhiza uralensis* (Licorice). Historically utilized in East Asian medicine to treat constipation and gastrointestinal disharmony, the formula is currently being evaluated in clinical trials for its potential to alleviate appetite loss (anorexia) and improve quality of life in patients with late-stage cancer. The therapeutic effects are attributed to the synergistic action of Rhubarb-derived anthraquinones, which stimulate intestinal motility, and Licorice-derived glycyrrhizin, which provides anti-inflammatory and cytoprotective benefits. In the context of cancer cachexia, the formula is hypothesized to resolve 'block and repulsion' states to improve nutritional intake and overall patient well-being.

Other names
Da-Huang-Gan-Cao-TangDai-O-Kan-Zo-ToTJ-84TJ84TJ 84Rhubarb and Licorice DecoctionDaHuang GangTsao Tang
02

Targets

Cyp (Cyclophilin family)ESR2 (ERβ)ABCB1 (P-glycoprotein)

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