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daledalin
- Development stage
- Discontinued
- Lead developer
- Pfizer
- Modality
- Small Molecules
01
Overview
Daledalin is a synthetic small molecule antidepressant developed in the early 1970s. It acts as a selective norepinephrine reuptake inhibitor (NRI), with no significant effects on serotonin or dopamine reuptake, and lacks antihistamine or anticholinergic properties. Daledalin was investigated for the treatment of depression but was never marketed. The compound features an indoline backbone and is chemically described as methyl[3-(3-methyl-1-phenyl-2,3-dihydro-1H-indol-3-yl)propyl]amine. It may also exhibit monoamine oxidase inhibitory activity in vitro, likely by acting as a substrate[1][2][5][7].
- Other names
- daledalindaledalinadaledaline
02
Targets
MAOA (Monoamine oxidase A)NET (Norepinephrine Transporter)
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