Drug intelligence / Profile preview

daledalin

Development stage
Discontinued
Lead developer
Pfizer
Modality
Small Molecules
01

Overview

Daledalin is a synthetic small molecule antidepressant developed in the early 1970s. It acts as a selective norepinephrine reuptake inhibitor (NRI), with no significant effects on serotonin or dopamine reuptake, and lacks antihistamine or anticholinergic properties. Daledalin was investigated for the treatment of depression but was never marketed. The compound features an indoline backbone and is chemically described as methyl[3-(3-methyl-1-phenyl-2,3-dihydro-1H-indol-3-yl)propyl]amine. It may also exhibit monoamine oxidase inhibitory activity in vitro, likely by acting as a substrate[1][2][5][7].

Other names
daledalindaledalinadaledaline
02

Targets

NET (Norepinephrine Transporter)MAOA (Monoamine oxidase A)

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