dammarenediol II

Dammarenediol II is a tetracyclic triterpene and a key biosynthetic precursor to ginsenosides, the primary bioactive compounds found in *Panax ginseng*. It is currently being investigated as a chemosensitizing agent and a novel chemotherapy adjuvant, particularly for its ability to enhance the efficacy of cytotoxic drugs like etoposide. Mechanistically, dammarenediol II acts as an inhibitor of O-linked N-acetylglucosamine transferase (OGT), which leads to a reduction in O-GlcNAcylation levels within cancer cells. This inhibition subsequently suppresses the Akt/GSK3β/mTOR signaling pathway, promoting apoptosis and increasing the sensitivity of various cancer cell lines—including liver (HepG2), lung (A549), and colorectal (Caco-2) cancers—to treatment. Research suggests it directly interacts with OGT to exert these effects, highlighting its potential in targeted oncology therapies.

Other names

(20S)-dammara-24-ene-3beta,20-dioldammarenediol-II20S-dammarenediol