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Dan Qi Tong Mai tablet
- Development stage
- Phase 1
- Lead developer
- Shanghai Institute of Materia Medica
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Dan Qi Tong Mai tablet (DQTM) is an innovative traditional Chinese medicine (TCM) formulation developed for the treatment of cardiovascular diseases, specifically coronary heart disease and chronic stable angina pectoris (blood stasis syndrome). It is composed of active fractions of *Salvia miltiorrhiza* (Danshen) salvianolic acids and *Panax notoginseng* (Sanqi) saponins (notoginsengnosides). The formulation was co-developed by the Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, and Taiji Group. DQTM has completed Phase I clinical trials evaluating its safety, tolerability, and pharmacodynamics in healthy volunteers (conducted at West China Hospital, Sichuan University), and is currently in Phase II clinical development.
- Other names
- Danqi Tongmai tabletDQTM tabletDQTT丹七通脉片
02
Targets
COX15-LOX (Lysyl Oxidase)PARP1 (Poly (adp-ribose) polymerase 1)
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