Drug intelligence / Profile preview

Danqi Tongluo Fang

Development stage
Preclinical
Administration
Oral
01

Overview

Danqi Tongluo Fang (also known as Danqi Tongluo Recipe) is a traditional Chinese medicine (TCM) formulation investigated for its therapeutic potential in musculoskeletal disorders, particularly cervical spondylosis and lumbar disc herniation. This complex herbal mixture comprises numerous active components, including quercetin, beta-sitosterol, stigmasterol, kaempferol, luteolin, ferulic acid, and tanshinone. Research utilizing network pharmacology has identified that the formulation acts through a multi-target, multi-pathway mechanism. Key biological targets include HSPA8, RPS27A, RPS27, and STAU1, which are involved in signaling pathways such as the MAPK and Wnt pathways. These interactions suggest that Danqi Tongluo Fang may help modulate inflammation and cellular stress responses associated with degenerative spinal conditions.

Other names
Danqi Tongluo Recipe丹芪通络方
02

Targets

HSPA8 (Heat shock cognate 71 kDa protein)STAU1 (Staufen-1 / STAU1)RPS27A (Ubiquitin-40S ribosomal protein S27a)TTK (TTK protein kinase)

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