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danshao gankang granules
- Development stage
- Unknown
- Lead developer
- Shanghai Huazhi Natural Medicine Technology Development
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Danshao Gankang Granules is a modern Traditional Chinese Medicine (TCM) compound formulation developed by Shanghai Huazhi Natural Medicine Technology Development Co., Ltd. for the treatment of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). The formulation is primarily composed of extracts from *Salvia miltiorrhiza* (Danshen) and *Paeonia lactiflora* (Baishao), which are traditionally used in Chinese medicine to address 'blood stasis' and 'damp-heat' syndromes. Mechanistically, the drug is designed to exert anti-inflammatory, anti-fibrotic, and lipid-regulating effects. It aims to improve liver function and reduce hepatic fat accumulation by modulating pathways involved in oxidative stress and pro-inflammatory cytokine production. The candidate has undergone Phase 2 clinical trials in China to evaluate its efficacy in improving histological and imaging markers of liver health in patients with NASH.
- Brand names
- Danshao Gankang Granules
- Other names
- Danshao Gankang Keli丹芍肝康颗粒
02
Targets
TNFA (Tumor necrosis factor alpha (soluble))TGFB1 (Transforming growth factor Beta-1 proprotein)
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