Drug intelligence / Profile preview

danshen polyphenolic acid

Development stage
Unknown
Modality
Small Molecules
Administration
Intravenous, Oral
01

Overview

Danshen polyphenolic acid refers to a mixture of water-soluble phenolic acids extracted from the root of Salvia miltiorrhiza Bunge (Danshen), a widely used traditional Chinese medicinal herb. The main active components are salvianolic acids, especially salvianolic acid A and B, which are known for their strong antioxidant, anti-thrombotic, anti-platelet aggregation, and anti-inflammatory activities. These compounds act primarily by inhibiting lipid peroxidation and platelet aggregation. Danshen polyphenolic acids have been extensively studied for their pharmacological effects in cardiovascular diseases (such as heart failure and brain infarction), cerebrovascular diseases, metabolic disorders like diabetes, as well as potential roles in cancer therapy. They are typically administered as injections or oral preparations in China for promoting blood circulation and removing blood stasis[1][5][7][9].

Brand names
Compound Danshen Dripping PillDanshen PianDanshen Injection
Other names
丹参多酚酸danshen polyphenol acidsalvianolic acids
02

Targets

KNG1 (High-molecular-weight kininogen)ATIII (Antithrombin III)CaSR (Extracellular calcium-sensing receptor)EDNRB (Endothelin receptor type B)F5 (Coagulation Factor V)SERPIND1 (Heparin cofactor II)PPARA (Peroxisome proliferator-activated receptor alpha)ANXA5EDNRA (Endothelin receptor type A)F10 (Factor Xa)CD4 (T lymphocyte surface antigen)F2R (Protease-activated receptor 1)

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