Drug intelligence / Profile preview

danshen sanjie

Development stage
Preclinical
Administration
Oral
01

Overview

Danshen Sanjie is a traditional Chinese medicine (TCM) formulation that contains danshen (Salvia miltiorrhiza) as its primary active ingredient. Danshen, also known as Chinese red sage, is widely used in TCM for its purported effects on promoting blood circulation, resolving blood stasis, and reducing inflammation. The "Sanjie" in the name suggests a multi-herb combination aimed at dispersing masses or resolving accumulations, though specific additional ingredients may vary by manufacturer and region. The mechanism of action of Danshen-based formulations involves multiple bioactive compounds that exhibit vasodilatory effects, antiplatelet activity (blood thinning), anti-inflammatory properties, and antioxidant actions. These mechanisms are believed to underlie their use in cardiovascular diseases such as angina pectoris and stroke[1][2][3]. Clinical studies suggest potential benefits for vascular cognitive impairment and inflammatory conditions like IBD; however, high-quality evidence remains limited[3][5][7].

Other names
Danshen Sanjie RecipeProfessor Xu Xian's Danshen Sanjie PrescriptionDanshen Sanjie Formula
02

Targets

AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)TP53 (Cellular Tumor Antigen p53 R175H)IL-6 (Interleukin 6)

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