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danshensu
- Development stage
- Phase 2
- Modality
- Small Molecules
- Administration
- Oral, Intragastric, Intravenous (preclinical)
01
Overview
Danshensu is a **natural water-soluble phenolic acid** (specifically, (R)-3-(3,4-dihydroxyphenyl)-2-hydroxypropanoic acid) derived from the root of *Salvia miltiorrhiza* (danshen), a widely used traditional Chinese medicinal herb[1][2][3][4]. It possesses **antithrombotic, cardioprotective, neuroprotective, antioxidant, anti-inflammatory, and antidepressant activities**[1][3][5][6]. Its pharmacological actions are mediated through several molecular pathways, including selective cyclooxygenase-2 (COX-2) inhibition (without substantial inhibition of COX-1), normalization of thromboxane A2/prostacyclin (TXA2/PGI2) balance, activation of the PI3K/Akt/ERK/mTOR and Nrf2 signaling pathways, modulation of AMPA receptors, upregulation of brain-derived neurotrophic factor (BDNF), and calcium and potassium channel modulation[1][3][5][6]. It has shown potential in the treatment of thrombosis, myocardial ischemia/reperfusion injury, neurodegenerative conditions (e.g., Parkinson's disease, Alzheimer's disease), ischemic stroke, and depression[1][3][5].
- Brand names
- Danshensu
- Other names
- Salvianic acid Adanshen suan aSalvianic aid ASodium danshensuDSS
02
Targets
AMPAR (AMPA receptor)EGFR (Epidermal growth factor receptor)BDNF (Brain-derived neurotrophic factor)CaV (Voltage-gated calcium channel protein complex)PGHS-1 (Prostaglandin G/H Synthase 1)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)MAPK3 (Mitogen-activated protein kinase 1)mTOR (Mammalian target of rapamycin kinase)AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)KCNQ1 (Potassium voltage-gated channel subfamily KQT member 1)
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