Drug intelligence / Profile preview

Danshu

Development stage
Unknown
Lead developer
Guizhou Dalong Pharmaceutical
Modality
Small Molecules
Administration
Oral
01

Overview

Danshu is a Traditional Chinese Medicine (TCM) therapeutic, typically formulated as a capsule, containing peppermint oil (Mentha haplocalyx oil) as its primary active ingredient. It is widely utilized in China for the management of biliary tract disorders, including chronic cholecystitis, cholelithiasis (gallstones), and the prevention of stone recurrence following endoscopic retrograde cholangiopancreatography (ERCP). The drug's efficacy is largely attributed to L-menthol, which acts as a calcium channel antagonist to relax biliary smooth muscle and the sphincter of Oddi, thereby facilitating bile flow and the passage of stones. Additionally, Danshu possesses choleretic properties, increasing the secretion and flow of bile to reduce biliary stasis and prevent stone formation.

Brand names
Danshu Capsule
Other names
Peppermint oil capsuleMentha haplocalyx oil capsule
02

Targets

KEAP1 (Kelch-like ECH-associated protein 1)PKM1 (Pyruvate kinase M1)HIF1A (Hypoxia-inducible factor 1-alpha)CYP2C9 (Cytochrome P450 family 2 subfamily C member 9)EGFR T790M (Epidermal growth factor receptor T790M mutant)

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