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Danxiong Granule
- Development stage
- Preclinical
- Lead developer
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Danxiong Granule is a Traditional Chinese Medicine (TCM) formulation developed by the Cancer Hospital of the Chinese Academy of Medical Sciences (CAMS) for the prevention and treatment of radiation-induced skin injury (radiation dermatitis). The preparation is a combination of *Salvia miltiorrhiza* (Danshen) and *Ligusticum chuanxiong* (Chuanxiong), herbs traditionally used to promote blood circulation and resolve blood stasis. Pharmacologically, Danxiong Granule works by improving local microcirculation in irradiated tissues, reducing the expression of pro-inflammatory and pro-fibrotic cytokines such as TGF-beta1, TNF-alpha, and IL-6, and providing antioxidant protection against radiation-induced reactive oxygen species. It is primarily used as an in-hospital preparation for patients undergoing radiotherapy for breast cancer and other malignancies to mitigate skin toxicity and improve quality of life.
- Brand names
- Danxiong Granule
- Other names
- Danxiong Keli丹雄颗粒
02
Targets
TNFA (Tumor necrosis factor alpha (soluble))TGFB1 (Transforming growth factor Beta-1 proprotein)IL-6 (Interleukin 6)
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