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Danzhi Xiaoyao Pills
- Development stage
- Preclinical
- Lead developer
- Shaanxi Provincial Hospital of Traditional Chinese Medicine
- Administration
- Oral
01
Overview
Danzhi Xiaoyao Pills (also known as Danzhi Xiaoyao Wan or Jiawei Xiaoyao Wan) is a classic Traditional Chinese Medicine (TCM) herbal formula used to treat liver qi stagnation accompanied by internal heat. It is a modification of the Xiaoyao San formula, enriched with *Paeonia suffruticosa* (Dan Pi) and *Gardenia jasminoides* (Zhi Zi) to clear heat and cool the blood. The formula is traditionally used to soothe the liver, clear heat, and resolve liver depression. Clinically, it is applied to treat a variety of conditions including emotional disorders (anxiety, depression), gynecological issues (premenstrual syndrome, irregular menstruation), and dermatological conditions such as psoriasis, particularly when these present with the TCM liver-depression syndrome pattern. The formula contains multiple active botanical ingredients including *Bupleurum chinense*, *Angelica sinensis*, and *Paeonia lactiflora*, which are thought to work synergistically to modulate the neuroendocrine-immune system.
- Brand names
- Danzhi Xiaoyao WanJiawei Xiaoyao Wan
- Other names
- Danzhi Xiaoyao WanJiawei Xiaoyao PillsPeony and Gardenia Formula
02
Targets
AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)FAAHESR1 (ERα)
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