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danzhi xiaoyao tablets
- Development stage
- Phase 4
- Lead developer
- The Ninth People's Hospital affiliated to Shanghai Jiaotong University Medical College
- Administration
- Oral
01
Overview
Danzhi Xiaoyao Tablets is a Traditional Chinese Medicine (TCM) formulation, also known as Jiawei Xiaoyao, which is a modification of the classic Xiaoyao San formula. It contains nine herbal ingredients: Moutan Cortex (Paeonia suffruticosa), Gardeniae Fructus (Gardenia jasminoides), Bupleuri Radix (Bupleurum chinense), Angelicae Sinensis Radix (Angelica sinensis), Paeoniae Radix Alba (Paeonia lactiflora), Atractylodis Macrocephalae Rhizoma (Atractylodes macrocephala), Poria (Poria cocos), Glycyrrhizae Radix et Rhizoma (Glycyrrhiza uralensis), and Menthae Haplocalycis Herba (Mentha haplocalyx). The formula is traditionally used to soothe the liver, clear heat, and resolve depression. In modern clinical research, it is being evaluated for its efficacy in treating burning mouth syndrome (BMS), particularly in patients characterized by qi depression with fire and deficiency. Its pharmacological effects are attributed to the modulation of the neuroendocrine-immune system, including the regulation of monoamine neurotransmitters like serotonin and dopamine, and the inhibition of pro-inflammatory cytokines such as TNF-alpha and IL-6.
- Brand names
- Danzhi Xiaoyao WanJiawei Xiaoyao Tablets
- Other names
- Moutan and Gardenia Xiaoyao TabletsJiawei Xiaoyao Sandanzhi xiaoyao tablets
02
Targets
ADORA1 (Adenosine receptor A1 subtype)IL-6 (Interleukin 6)IDO1 (Indoleamine 2,3-dioxygenase 1)MAOA (Monoamine oxidase A)MAOB (Monoamine oxidase B)TNFA (Tumor necrosis factor alpha (soluble))ADRB1 (β1)DRD (Dopamine receptors)5-HT (Serotonin receptors)
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