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dapagliflozin + linagliptin + metformin (Dios Lifesciences)
- Development stage
- Phase 3
- Lead developer
- AJU Pharm
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
**Dapagliflozin + linagliptin + metformin** is a fixed-dose oral combination of three antidiabetic drugs used in the management of type 2 diabetes mellitus when monotherapy or dual therapy is insufficient. - **Dapagliflozin**: A sodium-glucose co-transporter 2 (**SGLT2**) inhibitor that lowers blood glucose by increasing urinary glucose excretion. - **Linagliptin**: A dipeptidyl peptidase-4 (**DPP-4**) inhibitor that increases incretin levels, leading to increased insulin secretion and decreased glucagon release. - **Metformin**: A biguanide that decreases hepatic glucose production, reduces gastrointestinal absorption of glucose, and enhances insulin sensitivity. The combination enables complementary glucose-lowering mechanisms, improved glycemic control, and may reduce the risk of diabetes-related complications. It is used as an adjunct to diet and exercise in adults with type 2 diabetes.
- Brand names
- Linaget DMOndero-DMLinaliglip DapametJuslina DMLinaxa DMLinero-DMDapaglyn LMLinapil DMLinapride DMLaglin 5DMLaglin5DMLaglin-5DM
- Other names
- dapagliflozin + linagliptin + metformin hydrochloridedapagliflozin/linagliptin/metformindapagliflozin-linagliptin-metformin
02
Targets
ND1 (Mitochondrial electron transport chain complex I)SGLT2 (Sodium-glucose cotransporter protein subunit 2)
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