dapoxetine

Dapoxetine is a short-acting selective serotonin reuptake inhibitor (SSRI) developed specifically for the treatment of premature ejaculation in men aged 18 to 64 years. Unlike other SSRIs originally designed as antidepressants and requiring chronic dosing to reach steady-state concentrations in the body over weeks or longer periods of time, dapoxetine is rapidly absorbed and eliminated after oral administration. This pharmacokinetic profile makes it suitable for on-demand use 1–3 hours before sexual activity. Its mechanism of action involves inhibition of the serotonin transporter (SERT), leading to increased serotonin activity at postsynaptic receptors and resulting in delayed ejaculation. Originally created by Eli Lilly and later acquired by Johnson & Johnson (Janssen/ALZA), dapoxetine has been approved for use in several countries outside the United States but remains investigational or unapproved by the FDA[1][2][4][5][7].

Brand names

PriligyDapigraDaplongDaporinDasutraEverlongExtendaExtensilJoypoxKutubPrecoceSustinexDapoxil

Other names

dapoxetina (Spanish/Italian)dapoxetinum (Latin)