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dapsone + tazarotene
- Development stage
- Phase 4
- Lead developer
- Allergan
- Modality
- Small Molecules
- Administration
- Topical
01
Overview
Dapsone + tazarotene is a combination of two topical pharmaceutical agents: dapsone, a synthetic sulfone with anti-inflammatory and antibacterial properties, and tazarotene, a synthetic retinoid. This combination is used primarily in the treatment of acne vulgaris, targeting both comedonal and inflammatory acne lesions. Dapsone acts by inhibiting neutrophil myeloperoxidase and suppressing inflammation, while tazarotene modulates gene expression to normalize keratinocyte differentiation and reduce follicular hyperkeratinization. Clinical evidence supports improved efficacy for comedonal acne compared to tazarotene monotherapy. Both components are applied topically and individually approved by regulatory agencies for acne indications[1][5][7][2].
02
Targets
DHPS (Dihydropteroate synthase)MPO (Myeloperoxidase)RARA (Retinoic acid receptor alpha)RAR (Retinoic acid receptor)
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