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dapsone + tretinoin
- Development stage
- Unknown
- Lead developer
- Allergan
- Modality
- Small Molecules
- Administration
- Topical
01
Overview
Dapsone + tretinoin is a combination of two pharmaceutical agents commonly used in dermatology, particularly for the treatment of acne vulgaris. Dapsone is a sulfone antibiotic and anti-inflammatory agent that inhibits dihydropteroate synthase, blocking folic acid synthesis in bacteria and reducing neutrophil-mediated inflammation. Tretinoin is a retinoid that acts as an agonist at retinoic acid receptors (RARs), modulating gene expression to promote cell differentiation and reduce keratinocyte proliferation. The combination leverages both antibacterial/anti-inflammatory effects (from dapsone) and normalization of skin cell turnover (from tretinoin), making it effective for inflammatory acne lesions[4][6][8].
- Brand names
- Aczone (for dapsone topical)
02
Targets
RAR (Retinoic acid receptor)DHPS (Dihydropteroate synthase)
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