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DARPin Ec1
- Development stage
- Unknown
- Lead developer
- Uppsala University
- Modality
- Recombinant Proteins and Enzymes, Peptides
- Administration
- Intravenous
01
Overview
DARPin Ec1 is an engineered scaffold protein belonging to the designed ankyrin repeat protein (DARPin) class. It has a molecular weight of approximately 18.6 kDa and binds with high picomolar affinity (KD = 68 pM) to the epithelial cell adhesion molecule (EpCAM), a transmembrane glycoprotein overexpressed in various epithelial malignancies. DARPin Ec1 is primarily developed as a diagnostic imaging agent (when radiolabeled with isotopes such as technetium-99m, gallium-68, indium-111, or iodine-125) for single-photon emission computed tomography (SPECT) or positron emission tomography (PET) to visualize EpCAM expression in tumors and select patients for EpCAM-targeted therapies. It has been evaluated in a Phase I clinical trial for the visualization of EpCAM-expressing lung cancer.
- Other names
- 99mTc-(HE)3-Ec1[111In]In-Ec1[123I]I-DARPIN-Ec1[68Ga]Ga-Ec1-NOTA[99mTc]Tc(CO)3-(HE)3-Ec1[99mTc]Tc-Ec1DARPin Ec1Designed ankyrin repeat protein Ec1
02
Targets
EPCAM (Epithelial cell adhesion molecule)
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