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daunorubicin + cytarabine liposome (Jazz Pharmaceuticals plc, 041b4d)
- Development stage
- Phase 4
- Lead developer
- Jazz Pharmaceuticals
- Modality
- Small Molecules, Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
- Administration
- Intravenous
01
Overview
CPX-351 (Vyxeos) is a liposomal encapsulation of cytarabine and daunorubicin in a fixed 5:1 molar ratio. This formulation is designed to optimize the synergistic delivery of the two drugs to leukemia cells while minimizing systemic toxicity. It was developed by Celator Pharmaceuticals (now Jazz Pharmaceuticals) and is primarily indicated for the treatment of adults with newly-diagnosed therapy-related acute myeloid leukemia (t-AML) or AML with myelodysplasia-related changes (AML-MRC). The liposomal delivery system allows for prolonged exposure in the bone marrow, enhancing the efficacy of the traditional "7+3" chemotherapy regimen.
- Brand names
- Vyxeos
- Other names
- cytarabine and daunorubicin liposomeliposomal cytarabine and daunorubicin
02
Targets
DNADNA polymerase familyTOP2A (DNA topoisomerase II)
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