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daunorubicin and cytarabine liposome (Jazz Pharmaceuticals plc)
- Development stage
- Phase 4
- Lead developer
- Jazz Pharmaceuticals
- Modality
- Small Molecules, Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
- Administration
- Intravenous
01
Overview
CPX-351 (Vyxeos) is a liposomal encapsulation of cytarabine and daunorubicin in a fixed 5:1 molar ratio. This formulation is designed to optimize the synergistic delivery of the two antineoplastic agents to leukemia cells while minimizing systemic toxicity. Cytarabine is a pyrimidine nucleoside analog that inhibits DNA polymerase, thereby interfering with DNA synthesis, while daunorubicin is an anthracycline that intercalates into DNA and inhibits topoisomerase II, leading to DNA strand breaks. Developed by Jazz Pharmaceuticals following its acquisition of Celator Pharmaceuticals, CPX-351 is primarily indicated for the treatment of adults with newly-diagnosed therapy-related acute myeloid leukemia (t-AML) or AML with myelodysplasia-related changes (AML-MRC).
- Brand names
- Vyxeos
- Other names
- cytarabine:daunorubicin liposome injectionliposomal cytarabine and daunorubicin
02
Targets
DNADNA polymerase familyTOP2A (DNA topoisomerase II)
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