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DC-006

Development stage: Phase 2
Lead developer: Osaka University
Modality: Dendritic Cell Vaccines → Immune Effector Cells → Other Cell Types → Cell Therapies, Vaccines & Immunotherapeutics
Administration: Intradermal

Overview

**DC-006** is an investigational, personalized autologous dendritic-cell cancer vaccine developed for recurrent platinum-sensitive epithelial ovarian cancer. Patient-derived dendritic cells are transfected with mRNA from amplified ovarian cancer stem cells together with mRNAs encoding human telomerase reverse transcriptase and survivin. The vaccine is intended to present these tumor-associated antigens to the immune system and induce cytotoxic T-cell responses against ovarian cancer cells expressing hTERT, survivin, and ovarian cancer stem-cell antigens.

Other names: DC-006 vaccineDC006 vaccineDC 006 vaccineovarian cancer stem cell/hTERT/survivin mRNAs-loaded autologous dendritic cell vaccine

Targets

EGFR T790M (Epidermal growth factor receptor T790M mutant)DDR1 (Discoidin domain receptor 1)

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