dc-cholesterol

DC-cholesterol is a synthetic, **cationic cholesterol derivative** primarily used as a gene and drug delivery vehicle in research and experimental therapeutics. It enhances the formation of stable cationic liposomes, which are routinely combined with helper lipids such as DOPE (1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine) to form liposomes capable of encapsulating and delivering nucleic acids (DNA, siRNA, mRNA) and some small molecule drugs into mammalian cells. The positively charged ammonium group at the 3-position allows for electrostatic interaction with negatively charged nucleic acids, facilitating cellular uptake via pathways such as macropinocytosis and clathrin-mediated endocytosis. DC-cholesterol-based liposome formulations are noted for efficient gene transfection and relatively low cytotoxicity compared to other cationic lipids[3][4][8][9].

Brand names

DC-Cholesterol

Other names

DC-CholDC-Chol (hydrochloride)DC-cholesterol hydrochloride3β-[N-(N',N'-dimethylaminoethane)-carbamoyl]cholesterol hydrochlorideCholest-5-en-3-ol (3β)-3-[N-[2-(dimethylamino)ethyl]carbamate]hydrochloride3β-(N-(N',N'-dimethylaminoethane)carbamoyl)cholesterol166023-21-8