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DC-PNAT
- Development stage
- Phase 2
- Lead developer
- Naval Medical University
- Modality
- Dendritic Cell Vaccines → Immune Effector Cells → Other Cell Types → Cell Therapies, TCR-Engineered T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies
- Administration
- Intravenous, Subcutaneous
01
Overview
**DC-PNAT** is an investigational, personalized cellular immunotherapy developed at Naval Medical University for advanced biliary tract malignancies. The treatment comprises a dendritic-cell preparation and precision T cells generated against patient-specific tumor neoantigens. Dendritic cells are intended to present selected neoantigens and stimulate antigen-specific antitumor immunity, while the infused neoantigen-reactive T-cell component is intended to recognize and eliminate tumor cells displaying those neoantigens. In the registered Phase 1/2 study, DC-PNAT was administered with gemcitabine.
- Other names
- Dendritic cell-precision multiple antigen T cellsDendritic cell-precision T cell for neo-antigenPrecision T cells specific to personalized neo-antigen
02
Targets
pMHC (Peptide-MHC complex family)
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