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dCAR138-38
- Development stage
- Preclinical
- Lead developer
- Bio Basic
- Modality
- CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies, Gene Therapies
- Administration
- Intravenous
01
Overview
**dCAR138-38** is a dual chimeric antigen receptor (CAR) T cell therapy engineered to target both **CD138** (syndecan-1) and **CD38** antigens coexpressed on multiple myeloma cells. This construct couples single-chain variable fragments (scFvs) derived from indatuximab ravtansine and daratumumab to T cells, requiring simultaneous recognition of both antigens for activation. This design aims to enhance tumor specificity and reduce off-target toxicity compared to single-antigen CARs. In preclinical studies, dCAR138-38 demonstrated potent anti-myeloma activity and increased specificity for dual-expressing cells, with significantly prolonged survival in mouse models. The vector sequence was constructed and ordered from Bio Basic within the pUC57 vector system[1].
- Other names
- dCAR138-38dCAR-138-38dCAR 138-38
02
Targets
CD38 (Cluster of Differentiation 38)SDC1 (Syndecan-1)
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