Drug intelligence / Profile preview

dCBP-1

Development stage
Preclinical
Modality
PROTACs (E3 ligase recruitment) → Targeted Protein Degraders (TPDs) → Small Molecules, Bivalent/Multivalent Binders → Multivalent & Scaffold-Based Small Molecules → Small Molecules
Administration
Oral, Intravenous, Intraperitoneal
01

Overview

dCBP-1 is an experimental **small-molecule proteolysis-targeting chimera** that induces degradation of the lysine acetyltransferases p300 and CREB-binding protein by recruiting the E3 ubiquitin ligase cereblon. It was reported in preclinical research as a potent and selective p300/CBP degrader that suppresses enhancer-driven transcription, including oncogenic MYC-associated programs, and shows strong antiproliferative activity in multiple myeloma cell models. Based on the provided information, dCBP-1 appears to be a research compound described in the literature rather than a clinically developed pharmaceutical candidate, and no specific commercial drug developer, manufacturer for therapeutic use, or approved brand name has been identified.

02

Targets

EP300 (Histone acetyltransferase p300 (EP300) catalytic domain)CRBN (Cereblon)CREBBP (CREB-binding protein (CBP))

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