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DCVax-Prostate
- Development stage
- Phase 1
- Lead developer
- Northwest Biotherapeutics
- Modality
- Dendritic Cell Vaccines → Immune Effector Cells → Other Cell Types → Cell Therapies, Vaccines & Immunotherapeutics
- Administration
- Intradermal
01
Overview
DCVax-Prostate is an autologous dendritic cell-based vaccine developed by Northwest Biotherapeutics for the treatment of prostate cancer. The manufacturing process involves collecting a patient's own monocytes via leukapheresis, differentiating them into dendritic cells, and pulsing them with prostate-specific antigens, most notably Prostate-Specific Membrane Antigen (PSMA). These activated dendritic cells are then administered back to the patient, typically via intradermal injection, where they present the antigens to T-cells, thereby priming the immune system to identify and eliminate prostate cancer cells. This personalized immunotherapy approach is designed to enhance the body's natural anti-tumor response while maintaining a favorable safety profile.
- Brand names
- DCVax-Prostate
- Other names
- Autologous dendritic cell vaccine for prostate cancer
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