DD-CIP1

DD-CIP1 is a first-generation DNA damage chemical inducer of proximity (DD-CIP) designed to enhance the efficacy of PARP inhibitors in cancer therapy. It is a bivalent small molecule that functions by inducing chemically induced proximity between Poly [ADP-ribose] polymerase 1/2 (PARP1/2) and the chromatin remodeling protein Bromodomain-containing protein 4 (BRD4). By recruiting BRD4 to PARP-bound sites, DD-CIP1 rewires the traditional mechanism of PARP inhibition to actively trigger the DNA damage response (DDR) and apoptosis. It has demonstrated activity in cancer cell lines at nanomolar concentrations, serving as a proof-of-concept for a strategy to overcome resistance to conventional PARP inhibitors and expand their clinical utility beyond BRCA-mutated cancers.

Other names

DNA damage chemical inducer of proximity 1