DD-CIP2

DD-CIP2 is a bivalent small molecule designed as a DNA damage chemical inducer of proximity (DD-CIP). It functions by chemically inducing proximity between Poly [ADP-ribose] polymerase 1 and 2 (PARP1/2) and the chromatin remodeling protein Bromodomain-containing protein 4 (BRD4). This mechanism rewires the action of traditional PARP inhibitors, leading to the induction of the DNA damage response (DDR), cell cycle arrest, and apoptosis. DD-CIP2 has demonstrated nanomolar potency across diverse hematological and solid tumor cell lines, including cancer types that are typically insensitive to conventional PARP inhibitors. In preclinical studies using small-cell lung cancer (SCLC) xenograft models, DD-CIP2 showed significant antitumor efficacy and was well-tolerated at therapeutic doses.

Other names

DNA damage chemical inducer of proximity 2